κ receptor (oprk_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Opioid receptors κ receptor
GENE
OPRK1 (OPRK)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Kappa-type opioid receptor, K-OR-1, KOR-1
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
S
|
P
|
I
|
Q
|
I
|
F
|
R
|
G
|
10 |
E
|
P
|
G
|
P
|
T
|
C
|
A
|
P
|
S
|
A
|
20 |
C
|
L
|
P
|
P
|
N
|
S
|
S
|
A
|
W
|
F
|
30 |
P
|
G
|
W
|
A
|
E
|
P
|
D
|
S
|
N
|
G
|
40 |
S
|
A
|
G
|
S
|
E
|
D
|
A
|
Q
|
L
|
E
|
50 |
TM1 | |||||||||
P
|
A
|
H
|
I
|
S
|
P
|
A
|
I
|
P
|
V
|
60 |
I
|
I
|
T
|
A
|
V
|
Y
|
S
|
V
|
V
|
F
|
70 |
V
|
V
|
G
|
L
|
V
|
G
|
N
|
S
|
L
|
V
|
80 |
M
|
F
|
V
|
I
|
I
|
R
|
Y
|
T
|
K
|
M
|
90 |
ICL1 | TM2 | ||||||||
K
|
T
|
A
|
T
|
N
|
I
|
Y
|
I
|
F
|
N
|
100 |
L
|
A
|
L
|
A
|
D
|
A
|
L
|
V
|
T
|
T
|
110 |
T
|
M
|
P
|
F
|
Q
|
S
|
T
|
V
|
Y
|
L
|
120 |
ECL1 | TM3 | ||||||||
M
|
N
|
S
|
W
|
P
|
F
|
G
|
D
|
V
|
L
|
130 |
C
|
K
|
I
|
V
|
I
|
S
|
I
|
D
|
Y
|
Y
|
140 |
N
|
M
|
F
|
T
|
S
|
I
|
F
|
T
|
L
|
T
|
150 |
M
|
M
|
S
|
V
|
D
|
R
|
Y
|
I
|
A
|
V
|
160 |
ICL2 | |||||||||
C
|
H
|
P
|
V
|
K
|
A
|
L
|
D
|
F
|
R
|
170 |
TM4 | |||||||||
T
|
P
|
L
|
K
|
A
|
K
|
I
|
I
|
N
|
I
|
180 |
C
|
I
|
W
|
L
|
L
|
S
|
S
|
S
|
V
|
G
|
190 |
I
|
S
|
A
|
I
|
V
|
L
|
G
|
G
|
T
|
K
|
200 |
ECL2 | |||||||||
V
|
R
|
E
|
D
|
V
|
D
|
V
|
I
|
E
|
C
|
210 |
TM5 | |||||||||
S
|
L
|
Q
|
F
|
P
|
D
|
D
|
D
|
Y
|
S
|
220 |
W
|
W
|
D
|
L
|
F
|
M
|
K
|
I
|
C
|
V
|
230 |
F
|
I
|
F
|
A
|
F
|
V
|
I
|
P
|
V
|
L
|
240 |
I
|
I
|
I
|
V
|
C
|
Y
|
T
|
L
|
M
|
I
|
250 |
ICL3 | |||||||||
L
|
R
|
L
|
K
|
S
|
V
|
R
|
L
|
L
|
S
|
260 |
TM6 | |||||||||
G
|
S
|
R
|
E
|
K
|
D
|
R
|
N
|
L
|
R
|
270 |
R
|
I
|
T
|
R
|
L
|
V
|
L
|
V
|
V
|
V
|
280 |
A
|
V
|
F
|
V
|
V
|
C
|
W
|
T
|
P
|
I
|
290 |
H
|
I
|
F
|
I
|
L
|
V
|
E
|
A
|
L
|
G
|
300 |
ECL3 | TM7 | ||||||||
S
|
T
|
S
|
H
|
S
|
T
|
A
|
A
|
L
|
S
|
310 |
S
|
Y
|
Y
|
F
|
C
|
I
|
A
|
L
|
G
|
Y
|
320 |
T
|
N
|
S
|
S
|
L
|
N
|
P
|
I
|
L
|
Y
|
330 |
H8 | |||||||||
A
|
F
|
L
|
D
|
E
|
N
|
F
|
K
|
R
|
C
|
340 |
F
|
R
|
D
|
F
|
C
|
F
|
P
|
L
|
K
|
M
|
350 |
C-term | |||||||||
R
|
M
|
E
|
R
|
Q
|
S
|
T
|
S
|
R
|
V
|
360 |
R
|
N
|
T
|
V
|
Q
|
D
|
P
|
A
|
Y
|
L
|
370 |
R
|
D
|
I
|
D
|
G
|
M
|
N
|
K
|
P
|
V
|
380 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
α-neoendorphin, big dynorphin, β-endorphin, dynorphin A, dynorphin A-(1-8), [Leu]enkephalin, dynorphin A-(1-13), β-neoendorphin, dynorphin B, [Met]enkephalin